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Machinable bioceramic foams prepared by gelcasting method
Šťastný, Přemysl ; Částková, Klára (referee) ; Trunec, Martin (advisor)
Diploma thesis is focused on development of method for preparation individualized bioscaffolds prepared by milling of HA foam prepared by gel casting method and consolidated via epoxy curing reaction. Diploma thesis continues in bachelor thesis Modern processing methods of porous bioceramics. Literature search is filled in the newest knowledge from the field of bioactivity enhancement of scaffolds. Experimental part of diploma thesis described development of system for individualized scaffold manufacturing from HA suspension preparation, preparation of ceramic blocks used as material for machining to final blocks machining. Pressure strength of foam were evaluated, too. Chosen samples were coated with calcium polyphosphate coating for biological response enhancement. Coated samples were given for in-vivo test to partner university in Beijing under the terms of project FP7-NMP-2013-EU-China: "Bioscaffolds"
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Suspension Systems of Commercial Vehicles
Němeček, Vojtěch ; Dlugoš, Jozef (referee) ; Fojtášek, Jan (advisor)
This thesis follows up suspensions of lorry types. Thesis contains comprehensive overview of all commonly manufactured springs and shock-absorbers. Thesis is divides into five main parts. The first chapter is about oscillations, quality of suspensions and about other points connected to this theory. The second chapter has detailed overview of main types of suspensions. All types of currently used suspensions are listed, including coil suspensions, leaf suspensions, air suspensions and also shock-absorbers. The third chapter combine suspensions on different types of axles with their structure. The fourth chapter contains future of suspensions and electronic systems. In the conclusion is mentioned subjective evaluation of different types of vehicles
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Influence of formulation factors on the polyester nanoparticles size.
Športeň, Radek ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In the theoretical part of this thesis are described various types of nanoparticles, such as polymeric particles, liposomes, micelles and solid lipid nanoparticles. There are presented basic informations concerning methods of particles preparation in the laboratory conditions such as solutions of polymers dispersion methods by intensively stirring, coacervation of the solutions of polymers, polymeration methods in dispersions, and the exploitation of methods of dispersion of polymeric solutions in the supercritical solvents. In the folowing part of this thesis are some concise informations about the methods of evaluation of basic parameters of the nanoparticulate systems. There are summarised the trivial informations concerning granulometry of particles, their zeta potential, encapsulation effectivity of drugs, and also about the particles shape factor. The focus of this thesis is in the experiment, the main deal were in minimisation of the particle size prepared by the method of emulsification of biodegradable aliphatic α-hydroxyacids polyesters solutions. The main process arrangement was the selection of the appropriate solvent of polymers in the inner emulsion phase and the founding for the mostly efficient emulsifier during the dispersion process of polymer solutions. In process of the...
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Particles with antimicrobial silver.
Svobodová, Dana ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles Univerzity in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Dana Svobodová Supervisor: doc. RNDr. Milan Dittrich, CSc. Diploma thesis title: Particles with antimicrobial silver The theoretical part of this diploma thesis outlines a brief overview of recent findings on silver nanoparticles. Further, it concerns the kinetic properties of colloidal systems, methods of evaluating the size and shape of colloidal particles, mechanism of antimicrobial activity of colloidal silver and methods of preparation of nanoparticles. Concise information about the toxicity of silver nanoparticles and their impact on the environment is also included. In the experimental part comprehensive report on the results of measurements of granulometric characteristics of microparticles and nanoparticles by photon correlation spectroscopy (PCS) is included. The influence of various modifications of preparation procedures and processing on stability, size and the polydispersity of the size in terms of the volume and intensity diameter of the particles with elemental silver deposited on the surface was studied. Optimisation of the disperse system, quality control of the content of colloidal particles by subsequent reduction, the possibilities of using centrifuge and...
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Granulometry of nanoparticles from aliphatic acids copolymers.
Šrejma, Robert ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
The diploma thesis is focused on the study of influence on the composition of the system to the size of the nanoparticles from aliphatic polyesters with linear and branched molecules constitution. The emulsion method for distributing of solvent was chosen for preparation of nanoparticles. The theoretical part describes the nanoparticles, its origin and application. The following part is applying to biodegradable polymers, especially PLGA. There is also a mention of antifungal agent terbinafine. The nanoparticles are prepared of this substance. The process is described in the experimental part of thesis. The experimental part is testing different composition of samples. A main emphasis is on the choice of polymer solvent and emulsifier. There are also applied mixtures of solvents and emulsifiers. The important aspect is the evaluation of incorporated terbinafine, which has been the model drug. Prepared dispersions were exposed to stress conditions in the form of several days-storage and centrifugation.
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Granulometric characterisation of nanoparticles by the PCS method.
Jaworski, Jakub ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In the theoretical section of presented diploma thesis are discussed various nanoparticles such as micelles and liposomes, solid lipid nanoparticles and polymeric nanoparticles. Special attention was focused on copolymer PLGA. There are characterized different procedures in the preparation of nanoparticles. From the approches for nanoparticles evaluation are chosen measuring size of nanoparticles and their zeta potential. The experiment was almost unambiguously focused on study of effect of diffrent factors on nanopartlicles size and distribution from linear PLGA and PLGA used for branching of tripentaerythritol and polyacrylic acid. Keywords: nanoparticles, size, size distribution, zeta potential, interactions of nanoparticles
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Granulometric characterisation of nanoparticles by the PCS method.
Jaworski, Jakub ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In the theoretical section of presented diploma thesis are discussed various nanoparticles such as micelles and liposomes, solid lipid nanoparticles and polymeric nanoparticles. Special attention was focused on copolymer PLGA. There are characterized different procedures in the preparation of nanoparticles. From the approches for nanoparticles evaluation are chosen measuring size of nanoparticles and their zeta potential. The experiment was almost unambiguously focused on study of effect of diffrent factors on nanopartlicles size and distribution from linear PLGA and PLGA used for branching of tripentaerythritol and polyacrylic acid. Keywords: nanoparticles, size, size distribution, zeta potential, interactions of nanoparticles
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Suspension Systems of Commercial Vehicles
Němeček, Vojtěch ; Dlugoš, Jozef (referee) ; Fojtášek, Jan (advisor)
This thesis follows up suspensions of lorry types. Thesis contains comprehensive overview of all commonly manufactured springs and shock-absorbers. Thesis is divides into five main parts. The first chapter is about oscillations, quality of suspensions and about other points connected to this theory. The second chapter has detailed overview of main types of suspensions. All types of currently used suspensions are listed, including coil suspensions, leaf suspensions, air suspensions and also shock-absorbers. The third chapter combine suspensions on different types of axles with their structure. The fourth chapter contains future of suspensions and electronic systems. In the conclusion is mentioned subjective evaluation of different types of vehicles
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Particles with antimicrobial silver.
Svobodová, Dana ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
Charles Univerzity in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Candidate: Dana Svobodová Supervisor: doc. RNDr. Milan Dittrich, CSc. Diploma thesis title: Particles with antimicrobial silver The theoretical part of this diploma thesis outlines a brief overview of recent findings on silver nanoparticles. Further, it concerns the kinetic properties of colloidal systems, methods of evaluating the size and shape of colloidal particles, mechanism of antimicrobial activity of colloidal silver and methods of preparation of nanoparticles. Concise information about the toxicity of silver nanoparticles and their impact on the environment is also included. In the experimental part comprehensive report on the results of measurements of granulometric characteristics of microparticles and nanoparticles by photon correlation spectroscopy (PCS) is included. The influence of various modifications of preparation procedures and processing on stability, size and the polydispersity of the size in terms of the volume and intensity diameter of the particles with elemental silver deposited on the surface was studied. Optimisation of the disperse system, quality control of the content of colloidal particles by subsequent reduction, the possibilities of using centrifuge and...
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Influence of formulation factors on the polyester nanoparticles size.
Športeň, Radek ; Dittrich, Milan (advisor) ; Šnejdrová, Eva (referee)
In the theoretical part of this thesis are described various types of nanoparticles, such as polymeric particles, liposomes, micelles and solid lipid nanoparticles. There are presented basic informations concerning methods of particles preparation in the laboratory conditions such as solutions of polymers dispersion methods by intensively stirring, coacervation of the solutions of polymers, polymeration methods in dispersions, and the exploitation of methods of dispersion of polymeric solutions in the supercritical solvents. In the folowing part of this thesis are some concise informations about the methods of evaluation of basic parameters of the nanoparticulate systems. There are summarised the trivial informations concerning granulometry of particles, their zeta potential, encapsulation effectivity of drugs, and also about the particles shape factor. The focus of this thesis is in the experiment, the main deal were in minimisation of the particle size prepared by the method of emulsification of biodegradable aliphatic α-hydroxyacids polyesters solutions. The main process arrangement was the selection of the appropriate solvent of polymers in the inner emulsion phase and the founding for the mostly efficient emulsifier during the dispersion process of polymer solutions. In process of the...
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